Matheus Brandão Victor, Ph.d.

Dr. Mat Victor is an HHMI Hanna Gray Faculty Fellow in the Departments of Neuroscience and Stem Cell Biology & Regenerative Medicine at the Icahn School of Medicine at Mount Sinai. Dr. Victor earned his Ph.D. in Neuroscience from Washington University in St. Louis where he pioneered a novel cellular reprogramming approach to study the contribution of aging to neurodegeneration (Victor et al., Neuron 2014 and Victor et al., Nature Neuroscience 2018). His dissertation work was recognized with the National Science Foundation (NSF) Graduate Research Fellowship and a Research Dissertation Award (R36) from the National Institute of Aging. Dr. Victor conducted his postdoctoral training at the Picower Institute for Learning and Memory at MIT where he explored how genetic susceptibility in microglia, the brain-resident immune cells, contributes to neurodegeneration (Victor et al., Cell Stem Cell 2022 and Sun & Victor et al., Cell 2023). Additionally, Dr. Victor leveraged high-dimensional single-nucleus transcriptomic and epigenomic profiling of postmortem brains with functional modeling in human brain organoids to build the first cellular-resolution atlas of Alzheimer’s disease with psychosis (AD+P). This work revealed a previously unrecognized inflammatory-glutamatergic axis in the pathogenesis of neuropsychiatric symptoms in AD (Victor & Sun et al., bioRxiv 2025).

At Mount Sinai, Dr. Victor joins the faculty of the the Ronald M. Loeb Center for Alzheimer's Disease and the Friedman Brain Institute as an NIH FIRST Scholar. By combining over a decade of experience developing patient-derived in vitro models of the brain with expertise in profiling the postmortem human brain at the single-cell resolution, the Victor lab launched at Sinai in the Spring of 2025.

Dr. Victor was born and raised in Recife, Brazil. His family moved to Florida when he was 15 years old. His wife is also a Neuroscientist, and together they have two wonderful little boys.

Email: matheus.victor@mssm.edu

X: @MatBVictor

LinkedIn: https://www.linkedin.com/in/matheus-victor-652a03314/